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氟哌啶醇已广泛应用于治疗精神病。测定血液中该药物的浓度,将对药物代谢动力学、临床药理学等方面的研究工作提供重要的依据。其血药浓度一般极其微量,而常见于各国药典的化学分析法、分光光度法是难于测量这样微量组分的。 氟哌啶醇血药浓度的测定文献已有报导,其中有气相色谱法、气相色谱——质谱联用法以及放射免疫方法等。1979年Greene提出用HPLC的方法作为氟哌啶醇药物的分析方法。1980年Weals用HPLC方法进行包括氟哌啶醉在内的数种组分的分离与定性鉴别工作,取得满意结果。1981年Miyazaki报告了用HPLC法测定血液中的氟哌啶醇。
Haloperidol has been widely used in the treatment of mental illness. Determination of the concentration of the drug in the blood will provide an important basis for the study of pharmacokinetics, clinical pharmacology and other aspects. The blood concentration is generally extremely trace, but common in the national pharmacopoeia chemical analysis, spectrophotometry is difficult to measure such trace components. Haloperidol plasma concentration determination literature has been reported, including gas chromatography, gas chromatography - mass spectrometry and radioimmunoassay. 1979 Greene proposed the HPLC method as a method of analysis of haloperidol drugs. In 1980, Weals used HPLC method to separate and qualitatively identify several components including haloperidol, and achieved satisfactory results. 1981 Miyazaki reports the determination of haloperidol in the blood by HPLC.