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目的探讨VEGF基因在初发及复发、恶变的低级别胶质瘤中的表达的差异及意义。方法按照免疫组化方法即SP二步法对初发及复发、恶变的低级别胶质瘤标本进行VEGF的表达情况的检测,并分析上述基因在低级别胶质瘤复发、恶变过程中的表达差异。结果与初发的低级别胶质瘤标本相比较,VEGF在复发、恶变的胶质瘤中表达明显升高,其表达差异有统计学意义(P<0.05)。结论 VEGF在初发和复发、恶变中的胶质瘤的表达差异表明这些基因可能是明确胶质瘤复发、恶变的分子生物学指标之一。
Objective To investigate the difference and significance of the expression of VEGF gene in low-grade gliomas of primary and recurrent malignant lesions. Methods The expression of VEGF in low grade gliomas of primary and recurrent or malignant gliomas was detected by immunohistochemical method, ie SP two - step method. The expression of VEGF in low grade gliomas was analyzed. difference. Results Compared with newly diagnosed low grade gliomas, the expression of VEGF in recurrent and malignant gliomas was significantly increased (P <0.05). Conclusion The differential expression of glioma in primary and recurrent malignant tumors of glioma indicates that these genes may be one of the molecular biological indicators of glioma recurrence and malignant transformation.