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目的探讨大剂量缬沙坦在治疗糖尿病肾病中对患者尿蛋白排泄量和肾功能的影响。方法 90例糖尿病肾病(DN)患者,随机分为研究组和对照组,每组45例。在糖尿病常规治疗的基础上,对照组加服小剂量缬沙坦(80 mg),而研究组则加服大剂量缬沙坦(160 mg),治疗后比较两组患者尿蛋白排泄量和肾功能。结果治疗后,研究组24 h尿总蛋白、24 h尿微量蛋白明显下降,比较差异有统计学意义(P<0.05)。在肾功能方面,两组治疗前后均无明显改变,比较差异无统计学意义(P>0.05)。结论大剂量缬沙坦治疗糖尿病肾病疗效确切,可明显改善患者尿蛋白排泄量,保护肾脏功能,利于患者预后,值得推广。
Objective To investigate the effect of high-dose valsartan on urinary protein excretion and renal function in patients with diabetic nephropathy. Methods Ninety patients with diabetic nephropathy (DN) were randomly divided into study group and control group, with 45 cases in each group. On the basis of conventional diabetes mellitus, the control group received a small dose of valsartan (80 mg), while the study group was given a large dose of valsartan (160 mg). After treatment, urinary protein excretion and renal Features. Results After treatment, 24 h urine total protein and 24 h urine microalbumin in study group decreased significantly (P <0.05). In renal function, there was no significant difference between the two groups before and after treatment, the difference was not statistically significant (P> 0.05). Conclusion High-dose valsartan in the treatment of diabetic nephropathy is effective and can significantly improve the urinary protein excretion in patients with protection of renal function, which is conducive to the prognosis of patients and is worth promoting.