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目的 研究甲肝减毒活疫苗 (以下简称甲肝疫苗 )治疗慢性乙型肝炎 (CHB)的机制 .方法 140例 CHB随机分为治疗组和对照组 ,每组 70例 .治疗组采用甲肝疫苗治疗 ,对照组用一般保肝疗法 .在治疗前后分别检测乙型肝炎病毒标志 (HBVM) ,CD+ 3,CD+ 4 ,CD+ 4 /CD+ 8,α-干扰素 (IFN- α)及白细胞介素 - 6 (IL- 6 )水平 .结果 治疗组 HBe Ag 转阴率(42 .9% ) ,HBV DNA转阴率 (47.2 % )较对照组转阴率(2 1.4% ,2 4.0 % )差异明显 (P<0 .0 1,P<0 .0 5 ) ;治疗组CD+ 4 ,CD+ 4 /CD+ 8治疗后较治疗前有明显增高 (P<0 .0 5 ,P<0 .0 1) ;治疗组治疗过程中第 3,4周 IFN-α水平较治疗前有明显升高 (P<0 .0 5 ) ,并伴有 IL- 6水平一过性同步升高 .结论 甲肝疫苗可增强 T淋巴细胞功能 ,诱导机体产生内源性 IFN- α,促使 IL- 6水平增高 ,而达到清除或抑制 HBV复制 .甲肝疫苗可用于 CHB的治疗
Objective To study the mechanism of live attenuated hepatitis A vaccine (CHT) in treating chronic hepatitis B. Methods One hundred and forty CHB patients were randomly divided into treatment group and control group, with 70 cases in each group.The treatment group was treated with hepatitis A vaccine, Groups were treated with general hepatoprotective therapy, and HBVM, CD3, CD4, CD4 + CD8, IFN-α and IL-6 levels were measured before and after treatment - 6) .Results The negative conversion rate of HBeAg (42.9%) and HBV DNA negative rate (47.2%) in the treatment group were significantly lower than those in the control group (2.14%, 2.04%) .0 1, P <0.05). The treatment group had significantly higher CD + 4 and CD + 4 / CD + 8 levels than those before treatment (P <0.05, P <0.01) The levels of IFN-α in the 3rd and 4th week were significantly higher than those before treatment (P <0.05), accompanied by a transient increase of IL-6 level Conclusions Hepatitis A vaccine can enhance the function of T lymphocytes, Induction of the body to produce endogenous IFN-α, to promote IL-6 levels, and to clear or inhibit HBV replication. Hepatitis A vaccine can be used for the treatment of CHB