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目的:观察醒脑静注射液联合无创正压通气(NIPPV)早期治疗慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭患者的疗效。方法:42例COPD合并Ⅱ型呼吸衰竭患者随机分为常规治疗组和联合治疗(醒脑静注射液联合NIPPV)组,各21例。常规治疗组予常规治疗+NIPPV治疗;联合治疗组在常规治疗组基础上予醒脑静注射液40mL·d-1,均共7d。观察并比较神志觉醒时间、NIPPV时间、入住重症监护病房(ICU)时间、2组气管插管率和死亡率。结果:联合治疗组较常规治疗组神志觉醒时间、NIPPV时间和入住ICU时间均明显缩短(P<0.05),气管插管率显著降低(P<0.05)。结论:醒脑静注射液联合NIPPV早期治疗COPD更能够缩短NIPPV时间,改善患者意识,减少气管插管率,有利于患者预后。
Objective: To observe the effect of xingnaojing injection combined with noninvasive positive pressure ventilation (NIPPV) on early treatment of patients with chronic obstructive pulmonary disease (COPD) and type Ⅱ respiratory failure. Methods: Forty-two patients with COPD and type Ⅱ respiratory failure were randomly divided into routine treatment group and combination therapy (Xingnaojing injection and NIPPV group), 21 cases in each group. The conventional treatment group was treated with conventional therapy and NIPPV treatment. The combination treatment group was given routine treatment group on the basis of Xingnaojing injection 40mL · d-1, were a total of 7d. Observe and compare conscious wake time, NIPPV time, intensive care unit (ICU) time, two groups of tracheal intubation rate and mortality. Results: Compared with the conventional treatment group, the conscious waking time, NIPPV time and ICU stay in the combined treatment group were significantly shorter (P <0.05) and tracheal intubation rate was significantly lower (P <0.05). Conclusion: Xingnaojing injection combined with NIPPV early treatment of COPD can shorten the NIPPV time, improve patient awareness, reduce tracheal intubation rate, is conducive to the prognosis of patients.