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观察应用右旋糖酐４０分别于再灌注前后稀释血液对兔缺血再灌注心肌ＳＯＤ活性和丙二醛（ＭＤＡ）含量的影响。心肌缺血４５ｍｉｎ，再灌注１８０ｍｉｎ，复制急性心肌缺血再灌注模型。３０只兔随机分为３组，每组１０只。其中Ⅰ组（对照组）、Ⅱ组于再灌注后２０ｍｉｎ稀释血液；Ⅲ组于再灌注前２０ｍｉｎ稀释血液。结果：与Ⅰ组相比，Ⅱ组ＳＯＤ活性无明显变化，ＭＤＡ含量明显降低（Ｐ＜００５）；而Ⅲ组ＳＯＤ活性明显升高及ＭＤＡ含量显著降低（Ｐ＜００５）。提示：再灌注前后稀释血液对缺血再灌注心肌均有保护作用；而且再灌注前稀释血液的效果明显优于再灌注后稀释。
To observe the effect of dextran 40 on the activity of SOD and the content of malondialdehyde (MDA) in myocardial ischemia-reperfusion myocardium of blood diluted before and after reperfusion. Myocardial ischemia 45min, reperfusion 180min, replicate acute myocardial ischemia-reperfusion model. Thirty rabbits were randomly divided into 3 groups with 10 in each group. In group I (control group), group II was diluted 20 minutes after reperfusion; group III was diluted 20 minutes before reperfusion. Results: Compared with group Ⅰ, there was no significant change in SOD activity and the content of MDA in group Ⅱ (P <005), while the activity of SOD in group Ⅲ was significantly increased (P <005). Tip: before and after reperfusion diluted blood on ischemia-reperfusion myocardial protection; and the effect of diluting blood before reperfusion was significantly better than after reperfusion dilution.