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维甲酸广泛地用于银屑病和其它角化性疾病的治疗,包括痤疮,并被建议用于癌症的防治,本文报告2例服用依曲替酯(etretinate)后发生的淋巴瘤。例1.男,62岁。因患银屑病而服用依曲替酯50mg/d 10个月、45mg/d 5个月,效果良好。就诊前2周开始出现健忘和步态不稳,并有一次夜间大小便失禁。就诊时检查发现左侧轻度偏瘫,双侧足跖反射存在。CT 扫描发现右额部有一大肿瘤团块伴明显水肿。手术切除右侧额叶后病理检查证实为恶性 B 细胞淋巴瘤,确诊后停用依曲替酯。例2.女,19岁。因长期患银屑病和银屑病性
Retinoic acid is widely used in the treatment of psoriasis and other keratoses, including acne and is recommended for the prevention and treatment of cancer. Two cases of lymphoma, which occurred after taking etretinate, were reported. Example 1. Male, 62 years old. Because of psoriasis taking etomidate 50mg / d 10 months, 45mg / d 5 months, the effect is good. Amnesia and gait instability started 2 weeks before the visit and there was a nighttime incontinence. Examination revealed mild left hemiplegia examination, bilateral plantar reflex exists. CT scan found a large tumor mass on the right forehead with significant edema. Surgical removal of the right frontal lobe pathology confirmed malignant B cell lymphoma, diagnosis and withdrawal of etoposide. Example 2. Female, 19 years old. Because of long-term psoriasis and psoriasis