This article investigates the three-dimensional flow of Powell–Eyring nanofluid with thermophoresis and Brownian motion effects. The energy equation is considered in the presence of thermal radiation. The heat and mass flux conditions are taken into account. Mathematical formulation is carried out through the boundary layer approach. The governing partial differential equations are transformed into the nonlinear ordinary differential equations through suitable variables. The resulting nonlinear ordinary differential equations have been solved for the series solutions. Effects of emerging physical parameters on the temperature and nanoparticles concentration are plotted and discussed. Numerical values of local Nusselt and Sherwood numbers are computed and examined. This article investigates the three-dimensional flow of Powell-Eyring nanofluid with thermophoresis and Brownian motion effects. The energy equation is considered in the presence of thermal radiation. The heat and mass flux conditions are taken into account. Mathematical formulations are carried out through the The governing nonlinear differential equations have been solved for the series solutions. The governing nonlinear differential equations have been solved for the series solutions. The effects of emerging physical parameters on the temperature and the nanoparticles concentration are plotted and discussed Numerical values ​​of local Nusselt and Sherwood numbers are computed and examined.