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目的:探讨短期速效胰岛素联合长效胰岛素强化治疗方案对初诊2型糖尿病患者胰岛功能及氧化应激的影响。方法:选择30例初诊2型糖尿病患者,在一般治疗的基础上,应用短期速效胰岛素联合长效胰岛素强化治疗方案进行治疗,检测并比较患者治疗前后一般血清指标包括空腹血糖(FBG)、餐后2小时血糖(2h PPG)、糖化血红蛋白(HbA1c)、血清C肽(FCP),胰岛细胞功能指标包括胰岛素曲线下面积(AUG)、β细胞功能稳态模型评估(HOMA-B)、I30/G30、胰岛素抵抗指数(HOMA-IR)、胰岛素及C肽水平,以及氧化应激指标包括丙二醛(MDA)及超氧化物岐化酶(SOD)。结果:(1)与治疗前相比,患者治疗后FPG、2h PPG、HbA1c、AUG、HomaB、HomaIR及I30/G30水平均显著改善,差异均有统计学意义(P均<0.05);患者口服糖耐量试验0h、1h及2h胰岛素水平及C肽水平均显著回升,差异有统计学差异(P<0.05)。(2)治疗后,患者MDA水平显著降低,SOD水平显著升高,其差异有统计学意义(P<0.05)。结论:短期速效胰岛素联合长效胰岛素强化治疗方案可以明显改善初诊2型糖尿病患者胰岛功能,降低患者体内的氧化应激水平。
Objective: To investigate the effects of short-term fast-acting insulin combined with long-acting insulin therapy on islet function and oxidative stress in newly diagnosed type 2 diabetic patients. Methods: Thirty patients with newly diagnosed type 2 diabetes mellitus were selected. On the basis of general treatment, short-term fast-acting insulin combined with long-acting insulin regimen was used for treatment. The serum levels of FBG, 2h PPG, HbA1c, FCP, islet cell function index including area under the curve of insulin (AUG), homeostasis model assessment (HOMA-B), I30 / G30 , Insulin resistance index (HOMA-IR), insulin and C-peptide levels, and oxidative stress indicators including malondialdehyde (MDA) and superoxide dismutase (SOD). Results: (1) Compared with those before treatment, the levels of FPG, 2h PPG, HbA1c, AUG, HomaB, HomaIR and I30 / G30 in patients after treatment were all significantly improved (P all <0.05) Glucose tolerance test at 0h, 1h and 2h insulin levels and C peptide levels were significantly increased, the difference was statistically significant (P <0.05). (2) After treatment, the level of MDA and the level of SOD were significantly decreased (P <0.05). Conclusion: Short-term fast-acting insulin combined with long-acting insulin intensive treatment can significantly improve the newly diagnosed type 2 diabetic patients with islet function and reduce the level of oxidative stress in patients.