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目的:分析老年缺血性卒中合并急性肺损伤(ALI)患者血清Th1/Th2细胞因子水平表达。方法:连续选择近期住院的老年急性脑卒中患者93例,并按住院后5d内有无发生ALI分组,同期检测外周血辅助T细胞等指标。结果:93例老年缺血性卒中患者发生ALI31例,患病率33.33%,未发生ALI56例(对照组)。ALI组血清IFN-γ浓度及IFN-γ/IL-4比值均明显低于对照组,而血清IL-4浓度则显著高于后者(P均<0.05～0.01)。结论:老年缺血性卒中合并ALI患者存在明确Th2优势状态表达。
Objective: To analyze the serum levels of Th1 / Th2 cytokines in elderly patients with ischemic stroke complicated with acute lung injury (ALI). Methods: A total of 93 consecutive elderly hospitalized patients with acute stroke were enrolled in this study. ALI grouping within 5 days after hospitalization and peripheral blood helper T cells were performed during the same period. Results: There were 31 ALI cases in 93 elderly patients with ischemic stroke, the prevalence rate was 33.33%. No ALI occurred in 56 cases (control group). Serum levels of IFN-γ and IFN-γ / IL-4 in ALI group were significantly lower than those in control group, while serum IL-4 level was significantly higher than that in control group (all P <0.05-0.01). Conclusion: There is a clear expression of Th2 predominant state in elderly patients with ischemic stroke and ALI.