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癌胚抗原(carcinoenmbryonic antigen,CEA)是1965年由Gold和Freedman从结肠癌和胚胎结肠分离出的糖蛋白抗原,分子量200 000,属免疫球蛋白超基因家庭.常存在于胚胎组织及胃肠道、胆道的分泌液及血清中.CEA是对胃癌诊断最有用的标记物之一.在胃癌细胞显著过度表达与相应编码基因脱抑制有关.它执行细胞粘附分子功能,引起同型或异型凝聚反应.胃癌细胞合成CEA的功能很强,胃癌患者血清、胃液及癌组织内的CEA水平升高.本文从三方面探讨CEA与胃癌的关系.
Carcinoenmbryonic antigen (CEA) is a glycoprotein antigen isolated from Colon and embryonic colon by Gold and Freedman in 1965. It has a molecular weight of 200,000. It belongs to the immunoglobulin supergene family. It is often found in embryonic tissues and the gastrointestinal tract. The secretion of CEA in bile duct secretions and serum is one of the most useful markers for the diagnosis of gastric cancer. Significant overexpression of gastric cancer cells is associated with the de-repression of the corresponding coding genes. It performs the function of cell adhesion molecules, causing homotypic or heterotypic aggregation reactions. The function of synthesizing CEA in gastric cancer cells is very strong, and the CEA levels in serum, gastric juice and cancer tissues of gastric cancer patients are increased. This article discusses the relationship between CEA and gastric cancer from three aspects.