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亚洲的慢性乙型肝炎携带者约有30%-50%是由于围产期母婴传播造成的,宫内感染是其主要的传播途径,机体感染乙型肝炎病毒后,机体的免疫系统在抗病毒感染中起着重要保护作用,TNF-α主要由单核-巨噬细胞产生的单核因子,具有多种免疫调节作用。它与乙型肝炎、妊娠合并乙型肝炎的相关性引起很多国内外学者的关注。近年来的研究发现,TNF-α与许多妊娠生理或病理过程密切相关。其基因多态性受到越来越多的学者关注,TNF-α启动子区基因多态性通过影响TNF-α的转录调节来影响TNF-α的表达,因此研究TNF-α对了解HBV的发病机制及其作用有着深远的意义,为今后阻断乙型肝炎宫内感染提供新的靶点。
About 30% -50% of chronic hepatitis B carriers in Asia are caused by perinatal mother-infant transmission. Intrauterine infection is the main route of transmission. After the body is infected with hepatitis B virus, the immune system of the body is resistant Virus infection plays an important protective role, TNF-α is mainly produced by mononuclear macrophages mononuclear factor, with a variety of immunomodulatory effects. Its relevance to hepatitis B and pregnancy complicated with hepatitis B has attracted the attention of many scholars at home and abroad. Recent studies have found that TNF-α is closely related to many physiological or pathological processes of pregnancy. More and more scholars pay close attention to its gene polymorphism. The gene polymorphism of TNF-α promoter affects the expression of TNF-α by affecting the transcriptional regulation of TNF-α. Therefore, Mechanism and its role has far-reaching significance for the future block hepatitis B intrauterine infection provides a new target.