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目的:观察格拉司琼对呃逆的疗效。方法:207例呃逆患者分为2组,试验组101例,其中顽固性呃逆22例,采用格拉司琼治疗,3 mg静脉点滴,qd,疗程5 d。对照组106例,其中顽固性呃逆20例,肌内注射胃复安10 mg,bid,及针灸等常规方法治疗。结果:试验组总有效率93.1%,对照组总有效率79.3%(P<0.01),试验组的治愈率75.3%,对照组的治愈率45.3%(P<0.01)。试验组用药1 d起效率79.2%,对照组用药1 d起效率37.7%(P<0.01)。试验组无不良反应.对照组2例出现锥体外系症状。结论:格拉司琼治疗呃逆安全有效。
Objective: To observe the effect of granisetron on hiccup. Methods: A total of 207 patients with hiccups were divided into two groups. The experimental group consisted of 101 patients, including 22 intractable hiccups, treated with granisetron 3 mg intravenously qd for 5 days. Control group of 106 cases, of which 20 cases of intractable hiccups, intramuscular metoclopramide 10 mg, bid, and acupuncture and other conventional methods of treatment. Results: The total effective rate was 93.1% in the experimental group and 79.3% in the control group (P <0.01). The cure rate was 75.3% in the experimental group and 45.3% in the control group (P <0.01). In the experimental group, the efficiency was 79.2% on the first day and 37.7% on the first day in the control group (P <0.01). There was no adverse reaction in the test group, and extrapyramidal symptoms appeared in 2 cases in the control group. Conclusion: Granisetron is safe and effective in treating hiccups.