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目的探讨鼻咽癌放射治疗后所致脑干梗死的临床特点。方法报道1例鼻咽癌放射治疗后9年出现脑干梗死的患者,结合复习文献对该病的临床表现、影像学特点以及可能的发病机制予以分析。结果患者男性,42岁。急性起病,临床表现为左侧肢体无力和复视,既往有鼻咽癌放射治疗史,无明显血管危险因素。头颅MRI示脑干梗死,CTA示双侧大脑后动脉管腔狭窄。结论该患者脑干梗死可能与鼻咽癌放射治疗相关。
Objective To investigate the clinical features of brain stem infarction caused by radiation therapy of nasopharyngeal carcinoma. Methods A case of brain stem infarction occurred in 9 patients after radiotherapy of nasopharyngeal carcinoma was reported. The clinical manifestations, imaging features and possible pathogenesis of the disease were analyzed with reviewing literature. Results The patient was male, 42 years old. Acute onset, clinical manifestations of left limb weakness and diplopia, previous history of radiation therapy of nasopharyngeal carcinoma, no significant vascular risk factors. Head MRI showed brainstem infarction, CTA showed bilateral posterior cerebral artery stenosis. Conclusion This patient’s brainstem infarction may be related to radiotherapy of nasopharyngeal carcinoma.