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目的:比较四逆散传统汤剂、复方颗粒剂、配方颗粒剂中甘草苷和甘草酸的含量差异。方法:采用HPLC测定传统汤剂、复方颗粒剂、配方颗粒剂中甘草苷和甘草酸的含量,并对含量测定的方法进行考察。结果:甘草苷的含量在传统汤剂中最高,为1.357 mg/g,复方颗粒剂次之,为1.226 mg/g,配方颗粒剂最低,为1.150mg/g;甘草酸的含量在配方颗粒剂中含量最高,为1.467 mg/g,复方颗粒剂次之,1.254 mg/g,传统汤剂最低,为1.214 mg/g。结论:四逆散传统汤剂、复方颗粒剂、配方颗粒剂中甘草苷和甘草酸的含量存在差异,甘草苷的含量:传统汤剂>复方颗粒剂>配方颗粒剂;甘草酸:配方颗粒剂>复方颗粒剂>传统汤剂。
Objective: To compare the contents of liquiritin and glycyrrhizic acid among traditional decoction of Sini San, compound granule and formula granule. Methods: The content of liquiritin and glycyrrhizic acid in traditional decoction, compound granule and formula granule were determined by HPLC, and the content determination method was investigated. Results: The content of glycyrrhizin was the highest in traditional decoction of 1.357 mg / g, followed by compound granule of 1.226 mg / g and the lowest of formula granule of 1.150 mg / g. The contents of glycyrrhizin in the formula granule In the highest content of 1.467 mg / g, followed by compound granules, 1.254 mg / g, the lowest traditional decoction, 1.214 mg / g. Conclusion: The content of liquiritin and glycyrrhizic acid in traditional decoction, compound granule and formula granule are different. The content of liquiritin is traditional decoction> compound granule> formula granule; glycyrrhizic acid: formula granule > Compound Granule> Traditional Decoction.