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目的观察脑梗死患者血清同型半胱氨酸(homocysteine,Hcy)水平,并探讨其与颈动脉粥样硬化(Carotid ar-tery atherosclerosis,CAA)的相关性。方法检测54例脑梗死患者的血清同型半胱氨酸(Hcy)、血脂4项、空腹血糖(FBS)、血尿酸(UA),并应用彩色多普勒超声检测其颈动脉内膜-中层厚度(intimal-medial wall thickness,IMT),并与对照组25例的检测结果进行比较。结果脑梗死组和对照组血清Hcy水平升高者分别有40例和6例,占74.07%和24.00%,血清Hcy水平分别为(20.00±5.67)μmol/L和(13.80±2.10)μmol/L,两组比较差异均有统计学意义(均P<0.01);Hcy水平与颈动脉内膜-中层厚度呈显著正相关性(r=0.329,P<0.05),与血脂、FBS、血UA均无相关性(均P>0.05)。结论高Hcy血症是脑梗死重要危险因素,且与颈动脉粥样硬化的形成密切相关。
Objective To observe the level of serum homocysteine (Hcy) in patients with cerebral infarction and to explore its relationship with carotid ar-tery atherosclerosis (CAA). Methods Serum levels of homocysteine (Hcy), lipids (4), fasting blood glucose (FBS) and serum uric acid (UA) were measured in 54 patients with cerebral infarction. Carotid artery intima - media thickness (intimal-medial wall thickness, IMT), and compared with the control group of 25 cases of test results. Results Serum levels of Hcy in cerebral infarction group and control group were 40 cases and 6 cases, accounting for 74.07% and 24.00%, respectively. Serum Hcy levels were (20.00 ± 5.67) μmol / L and (13.80 ± 2.10) μmol / L (All P <0.01). There was a significant positive correlation between Hcy and carotid artery intima-media thickness (r = 0.329, P <0.05) No correlation (all P> 0.05). Conclusion Hyperhomocysteinemia is an important risk factor of cerebral infarction and is closely related to the formation of carotid atherosclerosis.