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在模拟人体温度 37℃条件下 ,进行硅灰石纤维粉尘与氨基酸作用的实验研究 ,测定在 72h内溶解过程中pH值和电导率 (κ)的变化。结果表明 ,硅灰石纤维矿物在氨基酸中发生的溶解作用与酸的性质有关 ,酸性氨基酸对矿物的溶解能力最强 ,中性次之 ,碱性最弱。硅灰石在酸性和碱性氨基酸中 8h左右出现溶解饱和点 ,而在中性氨基酸中 72h内无溶解饱和点 ,溶解度具有随时间的增加而呈线性增长的趋势。硅灰石的这种溶解特征表明 ,硅灰石在近中性的体液中长期耐久性不高 ,金属离子能被氨基酸所活化和迁移 ,溶解过程中金属离子与氨基酸发生的有机配合反应对氨基酸结构产生一定的破坏 ,有可能是导致正常的蛋白质受破坏的原因之一。
The effects of wollastonite fiber dust and amino acids were studied under the simulated human body temperature of 37°C, and the changes of pH and conductivity (κ) during 72 h were determined. The results show that the dissolution of wollastonite fiber minerals in amino acids is related to the nature of the acid. Acidic amino acids have the strongest solubility in minerals, followed by neutrality and weakest in alkalinity. Wollastonite appeared to have a saturation point of solubilization in acidic and basic amino acids at about 8 h, while there was no dissolution saturation point at 72 h in neutral amino acids, and the solubility increased linearly with time. The dissolution characteristics of wollastonite indicate that wollastonite has low long-term durability in near-neutral body fluids, metal ions can be activated and migrated by amino acids, and organic coordination reactions between metal ions and amino acids occur during dissolution. The structure causes some damage, which may be one of the reasons that cause normal proteins to be damaged.