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载脂蛋白M(apoM)是一种新发现的载脂蛋白 ,蛋白结构属于Lipocalin超家族 ,分子量约 2 4KD ,有一糖基侧链 ,人类apoM基因定位于人类 6号染色体短臂 ,紧邻MHC Ⅲ ,特异选择地在肝脏细胞和肾脏近曲小管上皮细胞中表达 ,在血液中apoM主要存在于高密度脂蛋白、少量在富含甘油三酯脂蛋白和低密度脂蛋白中。apoM在细胞内的表达调控及其生理、病理功能尚有待进一步研究。
Apolipoprotein M (apoM) is a newly discovered apolipoprotein whose protein structure belongs to the Lipocalin superfamily. It has a molecular weight of about 2 4 KD and has a glycosyl side chain. The human apoM gene is located on the short arm of human chromosome 6, next to MHC class III , Is specifically expressed in liver cells and renal proximal tubule epithelial cells. ApoM is mainly present in high-density lipoproteins and a small amount in triglyceride-rich lipoproteins and low-density lipoproteins in the blood. ApoM expression in the cell and its physiological and pathological function remains to be further studied.