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据2013年6月13日张润瑞(Cell Stem Cell,13 June,2013.DOI:10.1016/j.stem.2013.05.006)报道,哺乳动物基因组DNA中5-甲基胞嘧啶(5mC)的动态平衡调节胚胎和成年哺乳动物的神经发生。这种表观遗传修饰不仅控制神经前体细胞的增殖和存活,还会影响新生神经元的轴突生长。近期研究发现,5mC在体内可以被TET家族蛋白氧化成5-羟甲基化胞嘧啶(5hmC)等形式,而这些氧化修饰在早期胚胎和哺乳动物脑内有较高水平的分布。Tet酶催化的DNA氧化修饰在早期胚胎发育中的功能已有一些报道,但其在神经系统中的功能还鲜为人知。
As reported on June 13, 2013, Cell Stem Cell, 13 June, 2013. DOI: 10.1016 / j.stem.2013.05.006, the homeostasis of 5-methylcytosine (5mC) in mammalian genomic DNA Neurogenesis of embryos and adult mammals. This epigenetic modification controls not only the proliferation and survival of neural precursor cells but also the axonal growth of newborn neurons. Recent studies have found that 5mC can be oxidized by TET family proteins to 5-hydroxymethylated cytosine (5hmC) in vivo, and these oxidative modifications have a higher level of distribution in early embryonic and mammalian brain. The function of Tet-catalyzed DNA oxidative modification in early embryonic development has been reported, but its function in the nervous system is poorly understood.