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目的观察鼻咽癌调强放疗中腮腺体积以及剂量的动态变化。方法选取该院收治的鼻咽癌患者30例作为研究对象,所有患者均接受为期6~7周的调强放疗,每周对腮腺进行勾勒,观察每周腮腺的体积、照射剂量的变化情况。结果放疗过程中,患者每周两侧腮腺体积均显著小于治疗前,且第3周时最为显著(P<0.05)。患者每周两侧腮腺受照射剂量均显著高于计划受照射剂量,且第3周时最为显著(P<0.05)。结论调强放疗会影响两侧腮腺的体积与受照剂量,在变化最显著的第3周对放疗计划进行调整能更好地保护腮腺功能。
Objective To observe the dynamic changes of parotid gland volume and dose in intensity modulated radiotherapy for nasopharyngeal carcinoma. Methods Thirty patients with nasopharyngeal carcinoma admitted to our hospital were enrolled in this study. All patients received IMRT for 6 ~ 7 weeks. The parotid glands were sketched weekly to observe the changes of parotid gland volume and irradiation dose. Results During radiotherapy, the volume of parotid gland on both sides of each patient was significantly less than before treatment, and the most significant at the third week (P <0.05). The dose of parotid gland on both sides of the patient was significantly higher than that of the planned exposure dose at the third week, and the most significant was at the third week (P <0.05). Conclusions IMRT can affect the volume and dose of the parotid gland on both sides. Adjusting the radiotherapy plan in the third week with the most obvious change can better protect the function of the parotid gland.