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1例74岁男性患者,因冠心病冠脉搭桥术后给予阿托伐他汀钙20 mg,1次/d;单硝酸异山梨酯20 mg,2次/d;美托洛尔25 mg,2次/d;福辛普利钠10 mg,1次/d;阿司匹林肠溶片0.1 g,1次/d。用药约3个月患者出现皮肤、巩膜黄染,皮肤瘙痒,陶土样便,尿液呈深黄色。实验室检查:ALT85 U/L,AST80 U/L,TBil 246.8μmol/L,DBil 138μmol/L,总胆汁酸95.5μmol/L,ALP 221 U/L,γ-GT240 U/L,尿胆红素50μmol/L。停用阿托伐他汀钙,其余药物继续使用,并给予保肝治疗后患者症状好转。51 d后肝功能恢复正常。
One 74-year-old male patient received atorvastatin calcium 20 mg once per day for coronary artery bypass grafting, isosorbide mononitrate 20 mg twice daily, metoprolol 25 mg 2 Times / d; fosinopril sodium 10 mg, 1 / d; aspirin enteric-coated tablets 0.1 g, 1 time / d. About 3 months after treatment, patients with skin, yellowish sclera, skin itching, clay-like, dark yellow urine. Laboratory tests showed that ALT85 U / L, AST80 U / L, TBil 246.8 μmol / L, DBil 138 μmol / L, total bile acid 95.5 μmol / L, ALP 221 U / 50μmol / L. Stop using atorvastatin calcium, the remaining drugs continue to use, and give the liver symptoms after treatment. Liver function returned to normal after 51 days.