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目的:综述近年来在慢加急性肝衰竭疾病治疗方面所取得的研究进展以及研究成果。方法:查询与分析近年来有关慢加急性肝衰竭疾病治疗方面对应的学术研究成果以及期刊文献资料。结果:慢加急性肝衰竭是一种特殊的肝衰竭病症,病情危重,临床病死率高。慢加急性肝衰竭的发病机制与直接损伤、免疫介导损伤相关。针对临床确诊为慢加急性肝衰竭的病例,可通过人工肝支持系统、肝干细胞移植、肝移植、以及亚低温治疗等方法进行干预,以取得满意的治疗效果。结论:目前临床中针对慢加急性肝衰竭的内科治疗尚缺乏具有特效性的药物与治疗手段。为挽救患者生命,改善肝脏功能,需实现对慢加急性肝衰竭的早期诊断与治疗,在稳定生命体征的前提下早期行肝移植、人工肝支持系统、或肝干细胞移植治疗,并用亚低温治疗手段预防各类并发症,以巩固疗效。
OBJECTIVE: To summarize the research progress and achievements in the treatment of chronic and acute liver failure in recent years. Methods: Inquire and analyze the academic research results and journal literature about the treatment of chronic and acute liver failure in recent years. Results: Acute and chronic liver failure is a special condition of liver failure, the critical condition, high clinical mortality. The pathogenesis of chronic and acute liver failure is related to direct injury and immune-mediated injury. For the clinical diagnosis of slow and acute cases of acute liver failure, artificial liver support system, liver stem cell transplantation, liver transplantation, and mild hypothermia therapy intervention to obtain satisfactory therapeutic effect. Conclusion: At present, there are still lack of effective drugs and therapies for the medical treatment of acute and acute liver failure in clinic. In order to save the patient’s life and improve the liver function, it is necessary to realize the early diagnosis and treatment of slow and acute liver failure, treat the liver transplantation, artificial liver support system or hepatic stem cell transplantation under the condition of stable vital signs and treat with mild hypothermia Means to prevent various types of complications in order to consolidate the efficacy.