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增生性玻璃体视网膜病变(PVR)是一种常见的致盲眼病,表现为受损的玻璃体及视网膜的异常修复.PVR的形成涉及多种细胞因子,包括血小板衍生生长因子(PDGF)、血管内皮生长因子、肝细胞生长因子、转化生长因子β、表皮生长因子、肿瘤坏死因子α、结缔组织生长因子等.视网膜色素上皮(RPE)细胞涉及Jagged-1/Notch信号通路和RhoA/ROCK信号通路发生细胞上皮-间充质形态改变.RPE细胞的增生、迁移与PKC/ERK信号通路和Akt/mTORCl信号通路相关.非PDGF间接激活PDGF受体α是PVR形成的主要通路.对PVR的治疗开展实验研究,联合抑制多种细胞因子及应用抗氧化剂N-乙酰半胱氨酸均取得一定疗效.本文对相关细胞因子在PVR形成中的作用机制、信号通路及治疗相关的实验研究进行综述.“,”Proliferative vitreoretinopathy (PVR) is a leading cause of blindness and caused by abnormal repairs for the damaged vitreous and retina.The formation of PVR involves many cytokines,including platelet derived growth factor (PDGF),vascular endothelial growth factor,hepatocyte growth factor,transforming growth factor-β,epidermal growth factor,tumor necrosis factor-α,connective tissue growth factor,etc.The Jagged-1/Notch signaling pathway and RhoA/ROCK signaling pathway are involved in the epithelial-mesenchymal transition of retinal pigment epithelium (RPE) cells.The migration and proliferation of RPE cells are associated with the PKC/ERK and Akt/mTORCl signaling pathway.Non-PDGF cytokines indirectly active PDGF receptor α,which seems to be the key pathway in the development of PVR.The methods of cocktail neutralizing reagents targeted to multiple cytokines and the antioxidant N-acetylcysteine are effective in preventing PVR.Here,we reviewed the mechanisms and signaling pathways of multiple relevant cytokines involved in development and treatment of PVR.