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本文用体外培养测定细胞生长存活率的方法,探讨了人低分化鼻咽癌上皮细胞系(CNE—2Z)对6种常用抗癌药物的反应。观察到细胞生长存活率与药物的药理作用、剂量和作用时间有关,经回归分析得出不同药理作用类型的药物其作用浓度与时间和细胞生长存活率的关系,呈不同的回归曲线类型,并有各自的经验方程。作者还从药物对细胞生长抑制率,药物有效抑制浓度与临床用药量之比,以及药物半数致死量与有效抑制浓度之比,分析比较了各药物对 CNE—2Z 细胞的效应,结果提示在6种药物中,鼻咽癌可能对氟尿嘧啶比较敏感,且该药对机体的安全范围也较大。
In this study, we examined the response of human poorly differentiated nasopharyngeal epithelial cell line (CNE-2Z) to six commonly used anti-cancer drugs in vitro by measuring cell viability. The survival rate of cells was observed to be related to the pharmacological effect, dose and duration of action. The regression analysis showed that the relationship between the action concentration and the time and the cell survival rate of different pharmacological action types showed different regression curve types Have their own experience equation. The author also analyzed the effect of each drug on CNE-2Z cells from the ratio of the drug’s inhibitory rate to the cell growth, the ratio of the drug’s effective inhibitory concentration to the clinical dosage, and the ratio of the drug’s median lethal dose to the effective inhibitory concentration, Of the drugs, nasopharyngeal carcinoma may be more sensitive to fluorouracil, and the drug on the body’s safety range is also larger.