Proteostasis is critical for neuronal maintenance and survival,and its imbalance leads to neurodegeneration with the hallmark of protein misfolding and aggregation[1].Macroautophagy becomes a major route for the clearance of protein aggregates that are normally poor substrates for the proteasome,the other protein quality-control machinery[2].As a flux process,macroautophagy (hereafter referred to as autophagy) involves the formation of the autophagosome,a double-membrane vesicle for engulfing unwanted cellular components such as protein aggregates,and the fusion of autophagosomes with lysosomes that contain many potent proteases for final degradation[3].