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目的：通过测定谷胱甘肽相关酶活性及其在亚细胞分布，了解胎肾上腺在发育期间对活性代谢产物的解毒处理能力．方法：制备肾上腺、肝亚细胞组分．测定谷胱甘肽转移酶（ＧＳＴ）、还原酶、过氧化物酶．结果：ＧＳＴ在胎肾上腺微粒体、线粒体、胞浆中含量分别是肝各亚细胞组分中的３７３％、２７０％和１６７％．肾上腺微粒体ＧＳＴ活性与细胞色素Ｐ４５０、与氨基比林脱甲基酶活性皆呈正相关．肾上腺线粒体谷胱甘肽还原酶、过氧化物酶分别是肝线粒体中的５０６％和４８２％．结论：胎肾上腺有比胎肝更大的解毒能力．提示胎肾上腺兼有药物代谢器官的功能．
OBJECTIVE: To understand the detoxification of active metabolites in fetal adrenal gland during development by determining glutathione-related enzyme activity and its distribution in subcellular cells. Methods: Preparation of adrenal and hepatic subcellular fractions. Determination of glutathione transferase (GST), reductase, peroxidase. Results: The contents of GST in fetal adrenal microsome, mitochondria and cytoplasm were 373%, 270% and 167% of the subcellular components of liver, respectively. Adrenal microsomal GST activity and cytochrome P 450, and aminopyrine demethylase activity were positively correlated. The adrenal mitochondrial glutathione reductase and peroxidase are 506% and 482% of the liver mitochondria, respectively. Conclusion: Fetal and adrenal glands have a greater detoxification capacity than fetal liver. Tip fetal adrenal both drug metabolism organ function.