没食子酸(Gallic acid,GA)即3,4,5-三羟基苯甲酸,它存在于许多植物和中药内。经药理和临床证实,该类化合物可以增强冠脉血流量、改变血液流变,同时还具有增强纤维蛋白溶解活性以及促进血栓溶解等作用。特别是没食子酸丙酯(Propyl gallate,PG),是众所周知的抗氧化剂,它能预防诱发乳腺癌,对Lewis肺癌具有抑制和抗转移作用,从而被广泛地应用于临床和食品工业等。但这类物质的抗氧化机制尚不清楚,其活性中心位置的确凿的实验证据更未见报道。 Gallic acid (GA), 3,4,5-trihydroxybenzoic acid, is found in many plants and herbs. Pharmacologically and clinically confirmed that such compounds can enhance coronary blood flow, change the blood rheology, but also has enhanced fibrinolytic activity and promote thrombolytic effect. Propyl gallate (PG), in particular, is a well-known antioxidant that has been widely used in the clinical and food industries due to its ability to prevent breast cancer and to inhibit and metastasize Lewis lung carcinoma. However, the anti-oxidant mechanism of these substances is not yet clear, and the experimental evidence of their active center position has not been reported yet.