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TSG101编码一个多结构域的蛋白,其N端区与泛素结合酶同源。该蛋白是细胞内涵体分选复合物1的组成部分,同时也涉及到一系列细胞功能。近年来的研究表明:TSG101在乳腺癌等多种肿瘤中过度表达,是肿瘤进展过程中的正性调节器。
TSG101 encodes a multidomain protein whose N-terminal region is homologous to ubiquitin-binding enzymes. The protein is part of the cell endosomal sorting complex1 and also involves a series of cellular functions. In recent years, studies have shown that: TSG101 overexpression in a variety of tumors such as breast cancer is a positive regulator of tumor progression.