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Mechanical ventilation(MV)may aggravate lunginjury induced by a variety of injuries,includingintratracheal hydrochloric acid instillation,intratracheallipopolysaccharide(LPS)instillation with or withoutconcurrent saline lavage,intravenous LPS,orintravenous oleic acid.However,the mechanism for thisdetrimental effect of MV is unclear.The purpose of thepresent study was to determine the effect of MV on lunginjury induced by minimal LPS-instillation and on theLPS receptor CD_(14)in the lung.
Mechanical ventilation (MV) may aggravate lunginjury induced by a variety of injuries, including intratracheal hydrochloric acid instillation, intratrachealipopolysaccharide (LPS) instillation with or withoutconcurrent saline lavage, intravenous LPS, or intravenous oleic acid .However, the mechanism for this detrimental effect of MV is unclear. The purpose of thepresent study was to determine the effect of MV on lunginjury induced by minimal LPS-instillation and on theLPS receptor CD_ (14) in the lung.