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多项流行病学研究表明,HDL-C水平与冠心病(CHD)和糖尿病发病风险呈负相关。一种解释是,HDL-C是逆转血液中胆固醇向肝脏转运的重要物质,因此具有抗动脉粥样硬化作用。美国心脏病学会和美国心脏协会(ACC/AHA)认识到低HDL-C的重要性,在去年11月份发布的心血管风险评估指南中,将HDL-C纳入了心血管风险评估变量。低HDL-C的定义和病因HDL-C≤40mg/dL定义为低HDL-C水平,而对于女性和非洲裔美国人≤50mg/dL为低HDL-C水平。HDL-C水平极低(如<15mg/dL)可能是由于罕见的单基因疾病或雄性激素使用。广义上讲,HDL-C水平低有两个原因——遗传因素或非遗传因素。
A number of epidemiological studies have shown that HDL-C levels and coronary heart disease (CHD) and the risk of diabetes was negatively correlated. One explanation is that HDL-C is an important substance that reverses cholesterol transport to the liver in the blood and therefore has anti-atherogenic effects. Recognizing the importance of low HDL-C, the American College of Cardiology and the American Heart Association (ACC / AHA) included HDL-C in cardiovascular risk assessment variables in a guide to cardiovascular risk assessment released last November. The definition and etiology of low HDL-C HDL-C <40 mg / dL is defined as low HDL-C levels, whereas for women and African Americans <50 mg / dL is low HDL-C levels. Very low levels of HDL-C (eg <15 mg / dL) may be due to rare monogenic disease or androgen use. Broadly speaking, there are two reasons for low HDL-C levels - genetic or non-genetic.