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背景血管细胞黏附分子1(VCAM-1)和细胞间黏附分子1(ICAM-1)与心肌缺血的关系还未定论。目的探讨高血压人群VCAM-1和ICAM-1与缺血性心电图表现的关系。方法在蒙古族高血压现况研究的基础上,对高血压患者486例进行心电图检查、VCAM-1和ICAM-1的检测。用SPSS13.0进行统计分析。结果缺血性心电图表现组的VCAM-1、ICAM-1与非缺血性心电图表现组无显著性差异。经多因素logistic回归分析,各VCAM-1和ICAM-1水平对缺血性心电图表现的OR值均无统计学意义。结论血清VCAM-1和ICAM-1水平与高血压伴发缺血性心电图表现无关联。VCAM-1和ICAM-1与心肌缺血的关系仍需前瞻性的队列研究加以验证。
Background The relationship between vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) and myocardial ischemia has not yet been elucidated. Objective To investigate the relationship between VCAM-1, ICAM-1 and ischemic electrocardiogram in hypertensive population. Methods Based on the study of the prevalence of hypertension in Mongolia, 486 patients with hypertension were examined by electrocardiogram, VCAM-1 and ICAM-1. SPSS13.0 statistical analysis. Results There was no significant difference in VCAM-1, ICAM-1 and non-ischemic ECG in ischemic ECG group. After multivariate logistic regression analysis, the OR of VCAM-1 and ICAM-1 levels on ischemic electrocardiogram showed no statistical significance. Conclusions There is no correlation between serum VCAM-1 and ICAM-1 levels and hypertension manifestations of ischemic electrocardiogram. The relationship between VCAM-1 and ICAM-1 and myocardial ischemia still needs prospective cohort studies to be validated.