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目的探讨先天性甲状腺功能减低症(congenital hypothyroidism,CH)的筛查、诊断、治疗与随访工作的意义及存在的问题。方法对佛山市新生儿筛查中心确诊的201例CH患儿的临床资料进行回顾总结。结果新生儿疾病筛查是早期诊断甲低的最佳途径;暂时性甲低初始治疗剂量及停药时间有待进一步探讨;结论早期甲状腺素的替代治疗,完善的专科随访,能保证95%的甲低患儿智能发育达到正常。
Objective To explore the significance and existing problems of screening, diagnosis, treatment and follow-up of congenital hypothyroidism (CH). Methods The clinical data of 201 cases of CH diagnosed in neonatal screening center of Foshan City were retrospectively reviewed. Results Neonatal screening was the best way to diagnose hypothyroidism in early stage. The initial hypothyroidism dose and withdrawal time should be further explored. Conclusion Early thyroid hormone replacement therapy and perfect specialist follow-up can guarantee 95% Children with low intelligence to reach normal.