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目的评价应用最近研发的高廓清率超微超顺磁性三氧化二铁(USPIO)检出动脉粥样硬化斑块内血管炎症的能力。材料与方法本研究得到了动物实验伦理委员会的批准。应用人工诱导主动脉粥样硬化的兔模型测试最近引进的USPIO、P904,以标准型USPIO、ferumoxtran-10作为参照。
Objective To evaluate the ability of recently developed ultra-superparamagnetic iron oxide (USPIO) to detect vascular inflammation in atherosclerotic plaques. Materials and Methods This study was approved by the Animal Experimental Ethics Committee. A recently introduced USPIO, P904, was tested using a rabbit model of artificially induced aortic atherosclerosis, using the standard USPIO, ferumoxtran-10 as a reference.