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目的 :检测乳腺癌红细胞生成素受体 (Epo R)的表达与乳腺癌浸润性的关系。方法 :用Western印迹法检测 46例乳腺癌组织及其相邻非癌组织的 Epo R的表达 ,探讨其表达与浸润性的关系。结果 :6 0 .9% (2 8/ 46 )乳腺癌组织 Epo R表达阳性 ,其相邻非癌组织的 Epo R的表达率为 17.4% (8/ 46 )。32例 (78.2 % )浸润性乳腺癌组织中 2 5例表达 Epo R,14例 (2 1.4% )非浸润性乳腺癌组织中 3例表达 Epo R;Epo R阳性表达与其浸润性具有明显的相关性 ,P<0 .0 5。结论 :乳腺癌组织可有 Epo R的表达 ;Epo R的表达与乳腺癌浸润性密切相关。
Objective: To investigate the relationship between the expression of erythropoietin receptor (Epo R) and infiltration of breast cancer in breast cancer. Methods: The expression of Epo R in 46 cases of breast cancer and its adjacent non-cancerous tissues was detected by Western blotting, and the relationship between the expression of Epo R and invasiveness was explored. Results: The positive expression of Epo R was detected in 60.9% (28/46) breast cancer tissues, and the positive rate of Epo R in adjacent non-cancerous tissues was 17.4% (8/46). Twenty-five infiltrative breast cancers (32.2%) had Epo R expression, and 14 (22.4%) non-infiltrating breast cancers had Epo R expression. The positive expression of Epo R was significantly correlated with infiltrative Sex, P <0. 05. Conclusion: The expression of Epo R in breast cancer tissues may be related to the expression of Epo R in breast cancer.