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４－氨基吡啶（４－ＡＰ）２．６ｍｍｏｌ·Ｌ－１０．０２ｍＬｓｃ于小鼠颈背部可引起用后足爪搔抓注射部位的反应．以４－ＡＰｓｃ后５ｍｉｎ内发生搔抓鼠数为指标，观察不同药物对它的抑制作用．麻醉性镇痛药吗啡，哌替啶和芬太尼能明显抑制这一反应；弱镇痛药罗通定，安乃近，水杨酸钠和非镇痛药无效．局部麻醉药普鲁卡因，利多卡因或丁卡因与４－ＡＰ混合ｓｃ也可取消搔抓反应．结果表明这一方法可用于检测麻醉性镇痛药的镇痛作用和局麻药的局部麻醉作用．
4-Aminopyridine (4-AP) 2.6 mmol·L-10.02 mL sc in the back of the neck of a mouse can cause the reaction of the injection site with the rear foot scratching the scratches. The number of scratching mice within 4 min after 4-APsc was used as an index to observe the inhibitory effect of different drugs on it. The narcotic analgesics morphine, meperidine and fentanyl can significantly inhibit this response; weak analgesics Luo Tongding, metamizole, sodium salicylate and non-analgesic invalid. The local anesthetic procaine, lidocaine or tetracaine with 4-AP mixed sc can also cancel the scratching reaction. The results show that this method can be used to detect the analgesic effect of narcotic analgesics and local anesthetic effects of local anesthetics.