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目的 :本研究旨在探讨高龄高血压患者靶器官损害的相关危险因素,为临床上防治高龄高血压患者因高血压导致重要器官损害提供理论支持。方法 :采用自制调查问卷对我院心血管内科2011年3月至2013年9月收治的600例高龄高血压患者进行调查并收集临床资料,根据是否因高血压导致靶器官损害分为靶器官损害组(113例)和靶器官未损害组(487例);比较两组患者的一般资料及相关疾病信息,探究高血压导致靶器官受损的相关危险因素。结果 :靶器官损害组的平均年龄、具有吸烟史的比例、体质指数(BMI)、高血压病史、高血压3期患者的比例、收缩压(SBP)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)均显著的高于靶器官未损害组且上述指标在两组间的差异具有统计学意义;靶器官损害组的高密度脂蛋白(HDL-C)显著的低于靶器官未损害组且差异具有统计学意义;两组间性别、高血压病家族史、舒张压(DBP)、脉压(PP)、高同型半胱氨酸(Hcy)、尿酸(UA)水平比较差异不显著。结论 :相对于靶器官未损害组年龄越高、吸烟、BMI越高、高血压病史越长、高血压3期、收缩压严重偏高、较高的FPG、TC、TG、LDL-C、较低的HDL-C是高龄高血压患者靶器官损害的危险因素。
Objective: The purpose of this study is to investigate the risk factors of target organ damage in elderly patients with hypertension and to provide theoretical support for the prevention and treatment of hypertension-induced major organ damage in elderly patients with hypertension. Methods: A total of 600 elderly hypertensive patients admitted to our hospital from March 2011 to September 2013 were investigated by self-made questionnaire and clinical data were collected. According to whether the target organ damage caused by hypertension was divided into target organ damage (113 cases) and target organ uninjured group (487 cases). The general data and related disease information of two groups were compared to explore the related risk factors of target organ damage caused by hypertension. Results: The average age of target organ damage group, smoking history, body mass index (BMI), history of hypertension, proportion of patients with stage 3 hypertension, systolic blood pressure (SBP), fasting blood glucose (FPG), total cholesterol ), Triglyceride (TG) and low density lipoprotein (LDL-C) were significantly higher than those of target organ undamaged group, and there was significant difference between the two groups in the index; (HDL-C) was significantly lower than that of the target organ without injury, and the difference was statistically significant. The differences of gender, family history of hypertension, diastolic blood pressure (DBP), pulse pressure (PP), homocysteine Acid (Hcy), uric acid (UA) levels were not significantly different. CONCLUSIONS: The higher the smoking age, the higher the BMI, the longer the history of hypertension, the third stage of hypertension and the higher systolic blood pressure, and the higher FPG, TC, TG and LDL-C compared with those of the untreated target organ. Low HDL-C is a risk factor for target organ damage in elderly hypertensive patients.