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目的探讨经鼻双水平正压通气治疗早产儿呼吸窘迫综合征的治疗效果及应用价值。方法随机选择2014年4月—2015年10月在本院进行治疗的128例早产儿呼吸窘迫综合征患儿作为研究对象。按数字法将患者分为观察组(给予经鼻双水平正压通气)和对照组(给予经鼻持续气道正压通气)各64例,比较两组患者的临床疗效。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果治疗后两组患者氧分压、二氧化碳分压[(65.43±3.36)、(75.68±4.26)mm Hg(1 mm Hg=0.133 k Pa),(49.88±3.97)、(41.04±2.59)mm Hg]比较,差异均有统计学意义(均P<0.05)。治疗前后两组患者的氧分压、二氧化碳分压比较,差异均有统计学意义(t=41.052、28.882、19.972、6.599,均P<0.05)。观察组治疗有效率为95.31%(61/64),高于对照组的81.25%(52/64),差异有统计学意义(χ~2=6.117,P<0.05)。两组患者通气时间、氧疗时间、住院时间[(68.72±5.67)、(138.78±14.21)h、(24.66±4.75)d与(59.28±3.56)、(94.51±6.64)h、(17.46±2.14)d]比较,差异均有统计学意义(均P<0.05)。结论经鼻双水平正压通气治疗早产儿呼吸窘迫综合征可以有效增加潮气量与通气量,改善患儿的氧合功能,给予患儿更强的呼吸支持作用,值得在临床大力推广应用。
Objective To investigate the therapeutic effect and application value of nasal biphasic positive pressure ventilation on respiratory distress syndrome in premature infants. Methods A total of 128 children with respiratory distress syndrome who were treated in our hospital from April 2014 to October 2015 were selected randomly. According to the digital method, the patients were divided into two groups: observation group (positive nasal biphasic positive pressure ventilation) and control group (nasal continuous positive airway pressure ventilation), respectively. The clinical efficacy of the two groups were compared. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results After treatment, the partial pressure of oxygen, the partial pressure of carbon dioxide [(65.43 ± 3.36), (75.68 ± 4.26) mm Hg (1 mm Hg = 0.133 kPa), (49.88 ± 3.97), (41.04 ± 2.59) mm Hg ], The differences were statistically significant (all P <0.05). Before and after treatment, the partial pressure of oxygen and the partial pressure of carbon dioxide in both groups were significantly different (t = 41.052,28.882,19.972,6.599, all P <0.05). The effective rate of the observation group was 95.31% (61/64), which was higher than that of the control group (81.25%, 52/64). The difference was statistically significant (χ ~ 2 = 6.117, P <0.05). The duration of ventilatory time, oxygen therapy time and length of hospital stay in the two groups [(68.72 ± 5.67), (138.78 ± 14.21) h, (24.66 ± 4.75) d and (59.28 ± 3.56), (94.51 ± 6.64) h, (17.46 ± 2.14 ) d], the difference was statistically significant (all P <0.05). Conclusion Nasal bilevel positive pressure ventilation in the treatment of premature infants with respiratory distress syndrome can effectively increase the tidal volume and ventilation, improve the oxygenation function in children and give children a stronger respiratory support, which is worth popularizing in clinic.