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目的探讨支气管肺泡灌洗液(BALF)中CYFRA21-1、CEA、NSE检测对肺癌的诊断价值。方法检测40例肺癌和40例肺良性疾病患者支气管肺泡灌洗液及血清中CEA、CYFRA21-1、NSE的含量。结果肺癌组患者血清和支气管肺泡灌洗液中CEA、CYFRA21-1、NSE的含量显著高于肺良性疾病组,经比较差异有统计学意义(P<0.05)。肺癌患者支气管肺泡灌洗液中CEA、CYFRA21-1、NSE的含量显著高于血清中的含量。结论 BALF中CEA、CYFRA21-1、NSE的检测有助于肺癌尤其是早期肺癌的诊断,且临床价值优于血清。
Objective To investigate the diagnostic value of CYFRA21-1, CEA and NSE in the diagnosis of lung cancer in bronchoalveolar lavage fluid (BALF). Methods The levels of CEA, CYFRA21-1 and NSE in bronchoalveolar lavage fluid and serum in 40 patients with lung cancer and 40 patients with benign pulmonary disease were measured. Results The levels of CEA, CYFRA21-1 and NSE in serum and bronchoalveolar lavage fluid of patients with lung cancer were significantly higher than those of patients with benign lung disease, and the difference was statistically significant (P <0.05). The content of CEA, CYFRA21-1 and NSE in bronchoalveolar lavage fluid of lung cancer patients was significantly higher than that in serum. Conclusions The detection of CEA, CYFRA21-1 and NSE in BALF is helpful for the diagnosis of lung cancer, especially for early stage lung cancer, and its clinical value is better than that of serum.