TSH受体抗体(TRAb)刺激甲状腺引起Gra-ves甲亢。经治疗后,一些甲状腺刺激物如TSH和TRAb等能促使甲状腺抗原包括TSH受体的不断释放从而使该病反复。甲状腺素是否能抑制TSH分泌从而减少TRAb的产生而起治疗作用,对此作者进行了试验观察。 作者先用每日30mg他巴唑对109名甲亢患者治疗6个月,使其甲状腺功能全部恢复正常。然后将病人随机分成两组。第1组病人每日用100μg甲状腺素 TSH receptor antibody (TRAb) stimulates the thyroid causing Graves’ hyperthyroidism. After treatment, some thyroid stimuli, such as TSH and TRAb, can promote the recurrence of thyroid antigens including TSH receptors. Thyroxine can inhibit the secretion of TSH thereby reducing the production of TRAb and play a therapeutic role, the author of the experimental observation. The authors first treated 109 hyperthyroid patients for 6 months with 30 mg daily methimazole to return all their thyroid function to normal. The patients were then randomized into two groups. Group 1 patients daily with 100 g thyroxine