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目的本课题旨在仿真研究心血管系统对（ＬＢＮＰ）的反应。方法以Ｍｅｌｃｈｉｏｒ模型为基础，在静脉系统的分段和压力－容积关系、压力反射控制等方面加以改进，并引入了静脉紧张度的调节机制，建立了模拟ＬＢＮＰ下心血管系统反应的数学模型。模型包括７部分：血液重分配控制系统、左室灌注系统、左室收缩系统、外周循环系统、心率调节控制系统、外周阻力调节控制系统、静脉紧张程度控制系统。其中，心率和静脉紧张度受动脉压力感受器反射控制，而外周阻力则同时受动脉压力感受器和心肺压力感受器的反射控制。利用所建模型，仿真０～－１０．６４ｋＰａ（－８０ｍｍＨｇ）范围内ＬＢ－ＮＰ暴露时心血管系统的反应。为了验证模型的可靠性，进行了６名健康男性的－４．００ｋＰａ（－３０ｍｍＨｇ）、－６．６７ｋＰａ（－５０ｍｍＨｇ）及－９．３３ｋＰａ（－７０ｍｍＨｇ）ＬＢＮＰ试验。结果仿真ＬＢＮＰ时收缩压、平均压、心率、心输出量的变化以及血压反应过程。仿真结果与我们和文献报道的人体实验结果吻合较好。结论所建模型可以用来有效模拟ＬＢＮＰ下血液动力学的短期反应，对ＬＢＮＰ暴露时心血管系统反应机理的研究具有一定的意义。
Purpose This topic aims to simulate the cardiovascular system (LBNP) response. Methods The Melchior model was used to improve the segmentation and pressure-volume relationship of venous system and pressure reflex control, and the regulation mechanism of venous tension was introduced to establish a mathematical model to simulate cardiovascular system response under LBNP. The model includes seven parts: blood redistribution control system, left ventricular perfusion system, left ventricular systolic system, peripheral circulatory system, heart rate control system, peripheral resistance control system, venous tension control system. Among them, heart rate and venous tension are controlled by the arterial baroreceptors, while peripheral resistance is controlled by the reflex of the arterial baroreceptors and cardiorespiratory nociceptors. The proposed model was used to simulate the cardiovascular response during LB-NP exposure from 0 to -10.64 kPa (-80 mmHg). To verify the reliability of the model, -4.00 kPa (-30 mmHg), -6.67 kPa (-50 mmHg) and -9.33 kPa (-70 mmHg) LBNP tests were performed on 6 healthy males. Results LBNP simulated systolic blood pressure, mean pressure, heart rate, changes in cardiac output and blood pressure response. The simulation results are in good agreement with our human experiments reported in the literature. Conclusions The model can be used to effectively simulate the short-term hemodynamic response to LBNP. It is of great significance to study the cardiovascular response mechanism during LBNP exposure.