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嚼烟与含烟抽提物均可使BALB/3T3细胞发生形态学转化。酸化后的含烟抽提物和亚硝化后的嚼烟油提物的转化活性高於未酸化或未亚硝化者。从转化集落分离出来的细胞具有赘生转化的某些特征。研究结果提示,非吸烟烟草对使用者可能具有致癌危害作用。
BALB / 3T3 cells were morphologically transformed with both chewing tobacco and smoke-containing extracts. The conversion activity of acidified tobacco extract and nitrosated chewing tobacco oil extract was higher than that of non-acidified or non-nitrosated. Cells isolated from transformed colonies have some of the features of neoplastic transformation. The results suggest that non-smoking tobacco may be carcinogenic to users.