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水通道蛋白 - 2 (AQP2 )是一种加压素调控的四聚体通道蛋白 ,是水转运的特异性通道 ,主要表达于肾脏集合管主细管腔侧 (顶端 )的细胞膜上和细胞质内。研究发现不论是人类还是大鼠的内耳组织 ,水通道蛋白 - 2仅在内淋巴囊表达 ,其它内耳组织则未见表达 ;而 AQP2是肾脏尿液的重吸收 ,充血性心衰的水潴留等生理、病理机制的重要环节。这个发现无疑对有关内耳水代谢疾病的研究 ,如梅尼埃病 ,开辟了一个新的方向。 AQP2在肾脏和内淋巴囊的特异性表达 ,进一步揭示了耳肾相关的机制 ,也提示了内淋巴囊在耳肾相关中的重要地位
Aquaporin-2 (AQP2) is a vasopressin-regulated tetrameric channel protein that is a water-transport-specific channel that is mainly expressed on the plasma membrane and in the cytoplasm of the main stenosis (top) of the renal collecting manifold . Study found that both human and rat inner ear tissue, aquaporin - 2 only in the endolymphatic sac expression, no expression in other inner ear tissue; and AQP2 is renal reabsorption of urine, congestive heart failure water retention Physiology, pathology an important part. This finding undoubtedly opens up a new direction for research on water metabolism diseases of the inner ear, such as Meniere’s disease. The specific expression of AQP2 in the kidney and endolymphatic sac further revealed the auricular and renal related mechanisms and also suggested the importance of endolymphatic sac in ear and kidney related