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[目的]探讨谷红注射液辅助治疗冠心病患者经皮冠脉动脉介入术(PCI)术后再发心绞痛的临床疗效及其对患者炎性因子水平和血管内皮功能的影响.[方法]选择2014年1月至2016年12月本院收治的114例行PCI治疗后复发心绞痛的冠心病患者,根据随机数表法将其分为观察组和对照组,每组各57例.对照组患者给予阿司匹林肠溶片、硫酸氢氯吡格雷片、单硝酸异山梨酯片、酒石酸美托洛尔片治疗,观察组在对照组用药的基础上给予谷红注射液治疗,所有患者均治疗2周.比较两组患者治疗前后的心绞痛发生频率和持续时间,并对患者心绞痛症状的治疗效果进行评价,比较两组患者治疗前后血清高敏C反应蛋白(Hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、内皮素-1(ET-1)、一氧化氮(N())水平.同时应用多普勒彩色超声对患者血管内皮依赖性舒张功能(FMD)进行评价.[结果]两组治疗后心绞痛的发作频率及持续时间均低于治疗前,观察组治疗后心绞痛发作频率及持续时间均明显低于对照组,差异均具有统计学意义(P＜0.05).观察组治疗的总有效率为91.2％(52/57)显著高于对照组的82.5％(47/57),差异具有统计学意义(x2=5.368,P＜0.05).治疗后,两组患者血清Hs-CRP、TNF-α及IL-6水平均显著降低,观察组治疗后血清Hs-CRP、TNF-α、IL-6水平显著低于对照组,差异均具有统计学意义(P＜0.05).治疗后,两组血清ET-1水平显著降低,NO、FMD水平显著升高,观察组血清ET-1水平显著低于对照组,NO、FMD显著高于对照组,差异均具有统计学意义(P＜0.05).[结论]在冠心病PCI术后常规治疗的基础上,谷红注射液明显减少冠心痛PCI术后再发心绞痛频率并能够显著降低患者血清炎症因子水平,改善血管内皮功能.“,”[Objective]To investigate the therapeutic effect of Gu Hong Injection on angina pectoris after percutaneous coronary intervention (PCI) in patients with coronary heart disease and its influence on inflammatory reaction and vascular endothelial function.[Methods]From January 2014 to December 2016,114 patients with angina pectoris treated by PCI operation in our hospital were selected.According to the random number method;they were divided into observation group and control group with 57 cases in each group.Patients in the control group were treated with aspirin enteric-coated tablets,clopidogrel sulfate tablets,isosorbide mononitrate tablets and metoprolol tartrate tablets.The observation group was treated with Gu Hong Injection on the basis of the use of the control group.All the patients were treated for 2 weeks.The frequency and duration of angina pectoris before and after treatment were compared between the two groups.The therapeutic effect of angina pectoris was evaluated.Levels of serum Hs-CRP,tumor necrosis factor-α (TNF-a),interleukin-6 (IL-6) and endothelin-1 (ET-1) and nitric oxide (no) were compared between the two groups before and after treatment.At the same time,Doppler color ultrasound was used to evaluate vascular endothelium-dependent diastolic (FMD) function.[Results] After treatment,the attack frequency and duration of angina pectoris in the two groups were lower than those before treatment,and the attack frequency and duration of angina pectoris in the observation group were significantly lower than those in the control group.The difference was statistically significant (P ＜0.05).The total effective rate of treatment in the observation group was 91.2 ％ (52/ 57),which was significantly higher than that in the control group 82.5％ (47/ 57),and the difference was statistically significant (x2 =5.368,P ＜0.05).After treatment,the levels of serum Hs-CRP,TNF-and IL-6 were significantly decreased in both groups.The level of serum Hs-CRP,TNF-and IL-6 in the observation group was significantly lower than that in the control group (P ＜0.05).After treatment,the serum ET-1 level in the two groups was significantly decreased,the levels of NO and FMD increased significantly;the serum ET-1 level in the observation group was significantly lower than that in the control group.The NO and FMD were significantly higher than those of the control group,the difference was statistically significant (P ＜0.05).[Conclusion]On the basis of routine treatment after PCI operation for coronary heart disease,Guhong injection significantly reduce the frequency of recurrent angina pectoris after PCI and the level of serum inflammatory factors,and improve vascular endothelial function.