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目的:制作小鼠气道高敏感反应模型,以气道高敏的特异性病理生理改变为指标对其进行间接检测。方法:以卵清蛋白为变应原小鼠腹腔注射致敏,再经气道给予相同变应原诱导激发气道高敏感反应。检测免疫学、组织学、病理学等指标。结果:气道高感组血清卵清蛋白特异性IgE水平明显升高;支气管黏膜下及肺泡间隔嗜酸性粒细胞大量浸润。支气管内径缩小,部分呈菊花样改变;平滑肌层增厚;杯状细胞增生。结论:各项改变均符合气道高敏感反应病理生理特点,可间接证实气道高敏感反应发生。
OBJECTIVE: To establish a mouse model of airway hyperresponsiveness and to detect indirectly the pathophysiological changes of airway hypersensitivity. Methods: Ovalbumin was induced by intraperitoneal injection of allergen in mice, and the same allergen was given by airway to induce airway hypersensitivity reaction. Detection of immunology, histology, pathology and other indicators. Results: Serum ovalbumin-specific IgE levels were significantly increased in the high airway sensitization group, and bronchial submucosal and alveolar serous infiltration of eosinophils were abundant. Bronchial diameter narrowed, some chrysanthemum-like changes; thickening of the smooth muscle layer; goblet cell hyperplasia. Conclusion: All the changes are in line with the pathophysiological characteristics of airway hypersensitivity reaction, which can indirectly confirm the occurrence of airway hyperresponsiveness.