作者曾在1例活动性Wegener肉芽肿病患者中,检测到与乙醇固定的颗粒白细胞和单核细胞的胞浆起反应的抗体,称为抗胞浆抗体(ACPA)。于是,作者对41例确诊的Wegener肉芽肿病患者进行了ACPA的研究,并根据疾病活动性的标准,回顾性地作了记录。对其中19例患者,进行一年的前瞻性研究。同时测定了健康成人和其他具有血管炎、肾小球肾炎或肉芽肿性特征的“疾病”对照组中的 The authors have detected antibodies that react with the cytoplasm of ethanol-fixed granulocytes and monocytes in one patient with active Wegener’s granulomatosis called anti-cytoplasmic antibody (ACPA). As a result, the authors conducted a study of ACPA in 41 patients with confirmed Wegener’s granulomatosis and retrospectively documented them on the basis of disease activity. Nineteen of them were prospectively studied for one year. Simultaneous determination of “disease” in healthy adults and other vasculitis, glomerulonephritis or granulomatous controls