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目的：对国内开发睾丸酮微球长效注射剂进行初步可行性研究。方法：以生物降解医用材料乳酸（ＬＡ）乙醇酸（ＧＡ）共聚物（ＰＬＧＡ，ＬＡＧＡ８∶２）为载体，用溶剂挥发溶剂萃取法制备含睾丸酮的ＰＬＧＡ微球，并通过体外药物释放试验评价睾丸酮ＰＬＧＡ微球的药物缓释作用。结果：采用溶剂挥发溶剂萃取法可得到收率、粒径大小和分布及含药量均满意的睾丸酮ＰＬＧＡ微球。结论：睾丸酮ＰＬＧＡ微球有望成为新的睾丸酮长效制剂。
OBJECTIVE: To conduct a preliminary feasibility study on the long-term injection of testosterone microspheres in China. METHODS: PLGA microspheres containing testosterone were prepared by solvent evaporation-solvent extraction (PLGA, LAGA8: 2) biodegradable medical material. Release test to evaluate the sustained release of testosterone PLGA microspheres. RESULTS: Testosterone PLGA microspheres with satisfactory yield, particle size, distribution and drug content were obtained by solvent evaporation and solvent extraction. CONCLUSIONS: Testosterone PLGA microspheres are expected to become the new testosterone depots.