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目的 探讨血浆纤维蛋白原 (Fibrinogen ,Fib)水平对不稳定性心绞痛 (UAP)患者的预后判断价值。方法 对 80例UAP患者进行血浆Fib测定 ,同时观察住院期间的心脏事件发生率。结果 根据Fib水平将 80例UAP患者分为Fib正常组 (n =33,4 1 2 5 % ,Fib <4 0g/L)和Fib升高组 (n =4 7,5 8 75 % ,Fib≥4 0 g/L)。Fib升高组 30d内发生心脏事件 (急性心肌梗死、心脏性猝死及顽固性心绞痛 )的发生率明显高于Fib正常组 ( 4 8 94 %比 19 8% ,P <0 0 1)。结论 血浆Fib水平与UAP患者心脏事件的发生显著相关 ,对判断UAP患者预后有较好的预测价值。
Objective To investigate the prognostic value of plasma fibrinogen (Fibrinogen, Fib) in patients with unstable angina (UAP). Methods Eighty UAP patients underwent Fib plasma FIB measurement. The incidence of cardiac events during hospitalization was also observed. Results According to the level of Fib, 80 patients with UAP were divided into three groups: normal Fib group (n = 33,41 2 5%, Fib <40g / L) and Fib hyperplasia group (n = 47,58 75% 4 0 g / L). The incidence of cardiac events (acute myocardial infarction, sudden cardiac death and refractory angina) within 30 days in Fib elevated group was significantly higher than that in normal Fib group (48 94% vs. 19 8%, P 0 01). Conclusion The level of Fib in plasma is significantly correlated with the occurrence of cardiac events in patients with UAP and has a good predictive value in judging the prognosis of patients with UAP.