论文部分内容阅读
目的观察奥沙利铂联合卡培他滨治疗晚期大肠癌的疗效和毒副反应。方法48例均为术后有残留病灶或复发转移有可测量病灶的晚期的大肠癌患者,第1天静脉滴注奥沙利铂130mg/m2;卡培他滨2500mg/m2,分早晚2次口服,第1～14天,3周为一周期。结果48例患者CR3例,PR20例,SD13例,PD12例,近期有效率(CR+PR)为47·9%,中位生存期(MST)13个月,中位疾病进展时间(TTP)8·1个月。毒副反应主要为手足综合征、神经毒性,多为Ⅰ～Ⅱ度。结论奥沙利铂联合卡培他滨的方案疗效高,毒副反应患者能耐受,临床可以广泛推广应用。
Objective To observe the curative effect and toxicity of oxaliplatin combined with capecitabine in the treatment of advanced colorectal cancer. Methods Forty-eight cases were all patients with advanced colorectal cancer who had residual or relapsed metastasis and had measurable lesion. The patients were intravenously infused oxaliplatin 130 mg / m 2 on day 1 and capecitabine 2500 mg / m 2 on day 1 Oral, 1 to 14 days, 3 weeks for a cycle. Results Among the 48 patients, CR3, PR20, SD13 and PD12 had an effective rate of 47.9% (CR + PR), a median survival time (MST) of 13 months and a median time to progression of disease (TTP) of 8 · 1 month. Toxic and side effects mainly hand-foot syndrome, neurotoxicity, mostly Ⅰ ~ Ⅱ degrees. Conclusion The combination of oxaliplatin and capecitabine has a high curative effect and patients with toxic and side effects can tolerate. The clinical application can be widely promoted.