Novel regulation on excitatory synaptic transmission in cortical interneurons

来源 :Science Foundation in China | 被引量 : 0次 | 上传用户:liuyr821
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Inhibitory interneurons,which count 10%—20%of neurons in cortex,regulate the firing of excitatory neurons and are critical to sophisticated brain functions.Disruption of the excitability of cortical interneurons has been implicated in neurological and psychiatric disorders including epilepsy,schizophrenia and autism.Unlike the excitatory synapses of excitatory neurons whose molecular composition and regulation are extensively studied,our knowledge of these of inhibitory neurons is limited.Dr.Tao Yanmei,Professor in the Institute of Developmental and Regenerative Biology in Hangzhou Normal University,in collaboration with Dr.Lin Mei,Professor in the Institute of Molecular Medicine and Genetics,Georgia Regents University,published an article recently in Nature Neuroscience(2013,16:290—299)and reported that Leucine-Rich-Repeats and PDZ containing protein(LAP)Erbin regulates excitatory synaptic transmission Inhibitory interneurons, which count 10% -20% of neurons in cortex, regulate the firing of excitatory neurons and are critical to sophisticated brain functions. Disruption of the excitability of cortical interneurons has been implicated in neurological and psychiatric disorders including epilepsy, schizophrenia and autism .Unlike the excitatory synapses of excitatory neurons whose molecular composition and regulation are extensively studied, our knowledge of these inhibitory neurons is limited. Dr. Yao Yanmei, Professor in the Institute of Developmental and Regenerative Biology in Hangzhou Normal University, in collaboration with Dr . Lin Mei, Professor in the Institute of Molecular Medicine and Genetics, Georgia Regents University, published an article recently in Nature Neuroscience (2013, 16: 290-299) and reported that Leucine-Rich-Repeats and PDZ containing protein (LAP) Erbin regulates excitatory synaptic transmission
其他文献
请下载后查看,本文暂不支持在线获取查看简介。 Please download to view, this article does not support online access to view profile.
一  初中的一次考试,坐在我前面的是一名男生。每次传试卷的时候,他都是半转身子,把试卷恭恭敬敬地递过来,而且一定是我接到试卷了,他才转过身去。  高中时也是一次考试,我坐在最后负责收卷。我们组的第二位女生,总会在我把试卷收走后轻轻地对我说一声:“谢谢。”  也曾遇到过传卷子时头也不回就往后一扔导致试卷散落一地的人,但我一直记住的,却是那两位我不知姓名的同学。  许多举动的确不是义务,但很多时候,一
1 目的为了促进手球事业的发展,国家体委利用在北京举办亚洲青年手球锦标赛机会,组织全国青年队,业余队主教练,集中观摩学习,其目的是通过学习,使大家进一步了解亚洲手球运
本刊2015年第1期第60页《武汉江汉路城市公共艺术的文化社会心理分析》,作者郭媛媛,本论文属于“武汉东湖学院2014人文社科青年基金项目‘江城公共艺术参与性提升策略研究’
这篇文章是创新工场CEO李开复的自传《世界因你不同》的英译本Making a World of Difference的序言。  这是一篇关于中美交流、求同存异的文章。作者先后在微软中国研究院、谷歌中国任要职。他认为谷歌撤离中国归根结底是因为是中美两国之间缺乏互相了解;他提到在微软中国研究院时,去清华大学招聘实习生时的一个小插曲,他提到比尔盖茨对《财富》杂志说的一段话是怎样触怒了中国媒体。  每个国
翼城县民政局以建设勤政高效、清正廉洁的行政机关为宗旨,以加强精神文明建设为抓手,着力造就一支作风硬、业务精、服务优的干部职工队伍,促进全县民政事 Yicheng Civil Aff
迄今为止,三维CAD系统在机械制造行业中的小型企业中用得很少。作者一方面分析了该现象的原因,另一方面又指出了使三维CAD系统比二维CAD系统如何在实际工作中更快实现本质上的合理化。除
地震无情人有情,一方有难八方援。4月15日,得知青海玉树发生地震之后,中国残联、中国残疾人福利基金会紧急行动决定先期捐款100万元,用于灾区残疾人以及家属的安 Earthquake
浅议动量短语的前置现象李晓蓉在现代汉语中,"数词+量词"构成的短语大体可分为两类:一类是放在名词或名词性短语前充当定语,一类是放在谓词或谓词性短语的前后充当状语、补语。本文
评《近代汉语研究概况》杨荣祥近年来,近代汉语研究一改过去受冷落的状况,呈现出非常兴盛的势头。近日,我们又欣然读到蒋绍愚先生1991年底完稿的《近代汉语研究概况》(北京大学出版社