应用１∶３配比病例对照研究，了解浙江省海岛肝癌高发区洞头县原发性肝癌发病的危险因素，发现海岛居民肝癌发病与食用被污染甲壳类海产品和乙型肝炎病毒感染及心理等因素有较密切关系，提示少食甲壳类海产品，预防肝炎，多食绿色食品，保持乐观的人生态度可能有助于降低肝癌发病率。 A 1:3 matching case-control study was conducted to understand the risk factors of primary liver cancer in Dongtou County, a high incidence area of ​​island cancer in Zhejiang Province. It was found that the incidence and consumption of liver cancer in island residents were contaminated by crustacean seafood and hepatitis B virus infection and psychology. Such factors have a closer relationship, suggesting that eating less shellfish seafood, preventing hepatitis, eating more green food, and maintaining an optimistic attitude toward life may help reduce the incidence of liver cancer.